Document 0053
 DOCN  M9590053
 TI    [Study of reverse transcriptase selectivity. Substrate properties of new
       2',3'-unsaturated acyclic nucleotide analogs]
 DT    9509
 AU    Shirokova EA; Shipitsyn AV; Semizarov DG
 SO    Mol Biol (Mosk). 1995 Mar-Apr;29(2):461-71. Unique Identifier : AIDSLINE
       MED/95303113
 AB    A new series of nucleotide analogs, (Z)-pyrophosphoryl
       (phosphonyloxymethyl) but-2-enyl derivatives of pyrimidines and purines,
       was synthesized. Their substrate and inhibitory properties toward some
       DNA polymerases and reverse transcriptases were evaluated. They were
       shown to be selective inhibitors of HIV reverse transcriptase. The
       structure-substrate properties relationships for nucleotide analogs were
       discussed.
 DE    Base Sequence  DNA Polymerases/ANTAGONISTS & INHIB/METABOLISM  English
       Abstract  HIV/ENZYMOLOGY  Molecular Sequence Data
       Nucleotides/*METABOLISM  Reverse Transcriptase/ANTAGONISTS &
       INHIB/*METABOLISM  Substrate Specificity  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).