Document 0057
 DOCN  M9590057
 TI    CD3+/TCR-alpha beta- cells are important in protecting spinal cord
       tissues against Theiler's virus strain GD VII infection.
 DT    9509
 AU    Kohanawa M; Nakane A; Asano M; Minagawa T; Department of Microbiology,
       Hokkaido University School of; Medicine, Japan.
 SO    Microbiol Immunol. 1995;39(2):123-8. Unique Identifier : AIDSLINE
       MED/95303030
 AB    Intravenous infection with Theiler's virus strain GD VII causes acute
       encephalomyelitis in mice. Endogenous IFN-gamma produced in the spinal
       cord is important to protect the tissue in mice infected with this
       virus. Neither CD4+ cells nor CD8+ cells infiltrated the spinal cords of
       infected mice until Day 9 postinfection. However, the number of
       CD3+/TCR-gamma delta+ cells increased in the spinal cords of mice
       infected with the virus. These cells resided in the spinal cords of
       normal mice, and produced IFN-gamma as a result of stimulation by
       immobilized anti-CD3 mAb. Elimination of CD3+ cells by the
       administration of a specific mAb augmented viral replication and
       suppressed production of endogenous IFN-gamma. Depletion of TCR-alpha
       beta+ cells and ASGM1+ cells did not affect the viral replication, and
       did not alter the production of IFN-gamma. Therefore, CD3+/TCR-alpha
       beta- cells producing IFN-gamma play an important role in the protection
       of the spinal cord against Theiler's virus infection. These results
       suggest that CD3+/TCR-alpha beta- cells might be identical to TCR-gamma
       delta+ cells.
 DE    Animal  Antibodies, Monoclonal/THERAPEUTIC USE  Antigens, CD/ANALYSIS
       Antigens, CD3/*IMMUNOLOGY  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female  Flow Cytometry  Hamsters
       Interferon Type II/BIOSYNTHESIS  Leukocytes,
       Mononuclear/IMMUNOLOGY/METABOLISM  Mice  Mice, Mutant Strains
       Poliomyelitis/*IMMUNOLOGY/MICROBIOLOGY  Polioviruses,
       Murine/CLASSIFICATION/*GROWTH & DEVELOPMENT  Receptors, Antigen, T-Cell,
       alpha-beta/*IMMUNOLOGY  Spinal Cord/CYTOLOGY/*IMMUNOLOGY/MICROBIOLOGY
       Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).