Document 0065
 DOCN  M9590065
 TI    [Changes in the natural history of AIDS in patients from Mallorca and
       Ibiza: 1986-1992]
 DT    9509
 AU    Riera M; Altes J; Villalonga C; Salas A; Homar F; Picco G; Leyes M; Rifa
       J; Unitat d'Infeccioses, Hospital Son Dureta, Palma de Mallorca.
 SO    Med Clin (Barc). 1995 May 27;104(20):765-70. Unique Identifier :
       AIDSLINE MED/95302789
 AB    BACKGROUND: Longitudinal follow-up studies in patients with human
       immunodeficiency virus (HIV) infection and AIDS, which are fundamental
       for the knowledge of variations the natural history of this disease,
       have generally been carried out by Public Health Departments and in
       populations in which homosexual males predominate. The aim of the
       present study was to analyze the changes in the natural history of the
       patients diagnosed with AIDS in the islands of Mallorca and Ibiza.
       METHODS: A prospective study of the adult patients diagnosed with AIDS
       in Mallorca and Ibiza, from 1986 to 1992 was performed. RESULTS: The
       annual incidence of the cases of AIDS increased throughout the study.
       The mean age of the patients did not vary, and neither did that in
       relation to sexes. A progressive decrease was observed in CD4
       lymphocytes at the time of diagnosis (from 0.168 x 10(9)/l in 1986 to
       0.079 x 10(9)/l in 1992). There was an increase in heterosexual
       transmission patients with no known risk factors also increased over the
       period studied. The incidence of extrapulmonary tuberculosis decreased
       both as the form of presentation and in its global frequency. Pneumonia
       by Pneumocystis carinii increased mainly as a initial feature. The
       median survival was 547 days and did not vary significantly throughout
       the study. CONCLUSIONS: The epidemiologic and clinical study of AIDS in
       Mallorca and Ibiza, Spain is similar to that observed in other
       Mediterranean regions. The incidence of extrapulmonary tuberculosis has
       decreased.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Adolescence  Adult
       Aged  AIDS-Related Opportunistic Infections/EPIDEMIOLOGY  Cause of Death
       English Abstract  Female  Follow-Up Studies  Human  *HIV-1  Incidence
       Male  Middle Age  Prospective Studies  Risk Factors  Spain/EPIDEMIOLOGY
       Statistics  Survivors  JOURNAL ARTICLE

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