Document 0071
 DOCN  M9590071
 TI    [HIV infection: pathophysiology and its clinical features--clinical
       course and surrogate marker]
 DT    9509
 AU    Mimaya J; Division of Hematology and Oncology, Children's Hospital of;
       Shizuoka Prefecture.
 SO    Rinsho Ketsueki. 1995 May;36(5):424-34. Unique Identifier : AIDSLINE
       MED/95302654
 AB    Clinical courses and several hematological and serological markers were
       evaluated in 34 patients with HIV infection (32 with hemophilia and 2
       with homosexuality) who had been followed up at Shizuoka Prefecture
       Children's Hospital for 3 to 13 years, with the reference to the results
       observed in 1,082 patients with HIV infection registered with the
       Ministry of Health and Welfare Study Group, Natural History Committee.
       The results indicated as significant follow-up markers as (1) CD4- and
       CD8-positive lymphocyte count, (2) IgA, IgG and beta-2 microglobulin,
       (3) HIV p24 antigen and HIV culture isolation, and (4) serum HIV-RNA. Of
       these markers, the quantification of serum HIV-RNA seemed particularly
       useful for prognosis estimation, determination of therapy onset, and
       efficacy assessment of a given anti-HIV agent. In addition, we
       encountered 2 HIV-infected patients who seemed to meet the definition of
       long-term survivors. Factor analysis in these patients will be an
       important subject of investigation from a clinical point of view as
       well.
 DE    beta 2-Microglobulin/ANALYSIS  Antigens, CD8/ANALYSIS  Biological
       Markers/*ANALYSIS  CD4 Lymphocyte Count  English Abstract  Human  HIV
       Core Protein p24/ANALYSIS  HIV Infections/*DIAGNOSIS
       HIV-1/GENETICS/ISOLATION & PURIF  IgA/ANALYSIS  IgG/ANALYSIS  Lymphocyte
       Count  RNA, Viral/ANALYSIS  JOURNAL ARTICLE

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