Document 0090
 DOCN  M9590090
 TI    Apoptosis: molecular mechanisms and implications for human disease.
 DT    9509
 AU    Orrenius S; Institute of Environmental Medicine, Karolinska Institutet,;
       Stockholm, Sweden.
 SO    J Intern Med. 1995 Jun;237(6):529-36. Unique Identifier : AIDSLINE
       MED/95301987
 AB    Apoptosis is a highly regulated process of cell death with
       characteristic morphological changes that are distinct from necrosis.
       The biochemical machinery responsible for apoptotic cell death appears
       to be constitutively expressed in most, if not all, cells and can be
       triggered by a variety of signals, including sustained increases in the
       intracellular Ca2+ level. Apoptosis is the main mechanism of cell
       deletion during development, normal cell turnover, hormone-induced
       tissue atrophy, and pathological processes such as T-cell depletion in
       HIV/AIDS and neurodegenerative disease. The aim of this review is to
       briefly summarize current knowledge of the molecular mechanisms of
       apoptosis and its role in human disease.
 DE    Apoptosis/*PHYSIOLOGY  Disease/*ETIOLOGY  Human  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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