Document 0104
 DOCN  M9590104
 TI    Differential expression of various T cell surface markers in young and
       elderly subjects.
 DT    9509
 AU    Kudlacek S; Jahandideh-Kazempour S; Graninger W; Willvonseder R;
       Pietschmann P; Department of Internal Medicine III, University of
       Vienna,; Austria.
 SO    Immunobiology. 1995 Feb;192(3-4):198-204. Unique Identifier : AIDSLINE
       MED/95301302
 AB    The purpose of this study was to investigate the expression of
       lymphocyte markers in the peripheral blood of aged individuals and of
       young healthy blood donors. Results showed significant changes in the
       distribution of various T cell subpopulations. The CD3, CD4 and CD8
       surface expression was not different in the elderly patients when
       compared to the young subjects. The number of CD4+ T cells expressing
       CD45 RO isoform (memory cells) was increased in aged people; CD45 RA+
       CD4+ cells (naive cells) were decreased. The expression of the CD45 RB
       on the CD4+ cells was significantly lower in the elderly when compared
       to the young subjects. In contrast, the surface expression of CD45 RO
       and CD45 RB in the CD8+ cells was not statistically different in the
       young and aged subjects. The proportion of CD8+ cells coexpressing CD57
       was significantly increased in the elderly subjects. These results
       indicate age-dependent alterations of various surface markers of T
       cells. These observations may be of importance in the investigation of
       immunoregulatory mechanisms in geriatric patients with infection,
       autoimmune disease or cancer.
 DE    Adult  *Age Factors  Aged  Aged, 80 and over  Antigens, CD/BIOSYNTHESIS
       Antigens, CD45/BIOSYNTHESIS  Antigens, Differentiation,
       T-Lymphocyte/BIOSYNTHESIS  Antigens, Surface/*ANALYSIS  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female
       Human  Immunologic Memory  Male  T-Lymphocyte
       Subsets/CLASSIFICATION/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).