Document 0116
 DOCN  M9590116
 TI    QEEG in hemophiliacs with HIV infection.
 DT    9509
 AU    Riedel RR; Alper K; Bulau P; Brackmann HH; Niese D; Schieck U; Gunther
       W; Department of Psychiatry, University of Munich, Germany.
 SO    Clin Electroencephalogr. 1995 Apr;26(2):84-91. Unique Identifier :
       AIDSLINE MED/95300354
 AB    Conventional visual analysis of the EEG was performed on 320
       hemophiliacs infected with HIV, who spanned the range of the Walter Reed
       (WR) system for classifying clinical stage of HIV infection, and on 50
       HIV seronegative hemophiliac controls. Intermittent or paroxysmal
       slowing was the conventional EEG abnormality most commonly seen in early
       stages of HIV infection (stages WR1 and 2), with increased focal
       epileptiform activity and generalized slowing appearing in patients with
       the full clinical syndrome of AIDS (WR6). Slowing of the manually
       measured alpha rhythm was noted in stages WR2 and above. Quantitative
       EEG (qEEG) was obtained in a subset of 103 male HIV seropositive male
       hemophiliacs and 35 male HIV seronegative hemophiliac controls. The
       principal findings were a progressive relative increase in theta power
       with a tendency towards an anterior topographic distribution, and a
       progressive decline of spectral power in fast alpha relative to slow
       alpha with increasing severity of HIV disease. Significant qEEG
       differences from controls were apparent in WR2 subjects (seropositive
       with lymphadenopathy and without other constitutional symptoms), and
       were relatively greater in WR3-6 subjects. These results suggest
       sensitivity of qEEG to early CNS involvement with HIV infection.
 DE    Adult  Alpha Rhythm  *Electroencephalography  Female
       Hemophilia/COMPLICATIONS/*PHYSIOPATHOLOGY  Human  HIV
       Seropositivity/COMPLICATIONS/*PHYSIOPATHOLOGY  Male  Support, Non-U.S.
       Gov't  Theta Rhythm  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).