Document 0120
 DOCN  M9590120
 TI    Cytokine-producing mammary carcinomas in transgenic rats carrying the pX
       gene of human T-lymphotropic virus type I.
 DT    9509
 AU    Yamada S; Ikeda H; Yamazaki H; Shikishima H; Kikuchi K; Wakisaka A;
       Kasai N; Shimotohno K; Yoshiki T; Department of Pathology, Hokkaido
       University School of Medicine,; Sapporo, Japan.
 SO    Cancer Res. 1995 Jun 15;55(12):2524-7. Unique Identifier : AIDSLINE
       GENBANK/X52498
 AB    In two lines of transgenic rats (pX rats) from WKAH and F344 strains and
       carrying the human T-lymphotropic virus type I pX gene, undifferentiated
       mammary carcinomas developed predominantly in females starting at about
       5 months of age, and there was massive infiltration of granulocytes in
       the tumor tissue. The incidence of the tumor reached about 40% when the
       rats were 12 months old. mRNAs of both pX and host genes Gro and MIP-2,
       which are granulocyte chemoattractants of the interleukin 8 family, were
       highly expressed in the tumor tissue. Since expression and point
       mutation of several oncogenes and the antioncogene were not
       demonstrated, hitherto unidentified novel oncogenic pathways may be
       transactivated by the pX transgene in these pX rats.
 DE    Animal  Animals, Transgenic  Base Sequence  Cytokines/*BIOSYNTHESIS  DNA
       Primers  Female  *Genes, Viral  Human  HTLV-I/*GENETICS
       Immunohistochemistry  Mammary Neoplasms,
       Experimental/*IMMUNOLOGY/PATHOLOGY  Molecular Sequence Data
       Monokines/BIOSYNTHESIS  Organ Specificity  Polymerase Chain Reaction
       Rats  Rats, Inbred F344  Rats, Inbred Strains  Receptors,
       Prolactin/BIOSYNTHESIS  Retroviridae Proteins, Oncogenic/*BIOSYNTHESIS
       Support, Non-U.S. Gov't  Transforming Growth Factor beta/BIOSYNTHESIS
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).