Document 0121
 DOCN  M9590121
 TI    New directions in research: report from the 10th International
       Conference on AIDS.
 DT    9509
 AU    Berger PB; Department of Family and Community Medicine, Wellesley
       Hospital,; Toronto, Ont.
 SO    Can Med Assoc J. 1995 Jun 15;152(12):1991-5. Unique Identifier :
       AIDSLINE MED/95300044
 AB    Research findings presented at the 10th International Conference on
       AIDS, held in Yokohama, Japan, in August 1994, indicate that few
       advances have been made in standard antiretroviral therapy for HIV
       infection. The perinatal administration of AZT (zidovudine) was reported
       to reduce transmission of HIV from mother to child, and its use in
       combination with acyclovir appears to improve survival among patients
       with advanced disease. Other research has focused on asymptomatic
       patients with long-standing HIV infection. Their survival may be related
       to the activity of cell antiviral factor, a cytokine produced by CD8+
       cells. In gene therapy research, one approach involved the genetic
       alteration of target cells to enable them to render the virus harmless.
       A second approach consisted of enhancing the function of CD8+ cells to
       allow them to compensate for dysfunctional CD4+ cells. The author
       believes that gene therapy may offer the greatest hope of an effective
       treatment for HIV infection.
 DE    *Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/PHYSIOPATHOLOGY/
       THERAPY  Antiviral Agents/THERAPEUTIC USE  Gene Therapy  Human
       Immunotherapy, Adoptive  Research  World Health  MEETING REPORT  JOURNAL
       ARTICLE

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