Document 0130
 DOCN  M9590130
 TI    Treatment with the alpha-glucosidase 1 inhibitor 6-O-butanoyl
       castanospermine reduces the detection of LFA-1 (CD18/CD11a) by
       monoclonal antibodies.
 DT    9509
 AU    Bridges CG; Taylor DL; Kang MS; Brennan TM; Tyms AS; MRC Collaborative
       Centre, London, UK.
 SO    Glycobiology. 1995 Mar;5(2):243-7. Unique Identifier : AIDSLINE
       MED/95299228
 AB    The antiviral clinical candidate 6-O-butanoyl castanospermine (MDL
       28,574), an alpha-glucosidase 1 inhibitor, was examined for its effect
       on elementary parameters of immune function. It did not affect the
       mitogenic response of uninfected human mononuclear leukocytes or the
       detection of a range of cell surface markers, with the exception of the
       integrin LFA-1 (CD18/CD11a), which was reduced, after cell growth in
       vitro. The detection of LFA-1 was also reduced on both human and murine
       cells after oral administration of the compound to xenochimaeric or
       normal mice, respectively. Altered LFA-1 expression or function may
       contribute to reduced cell adhesion and the observed reduction in the in
       vitro allogeneic response by uninfected cells, as well as the previously
       described prevention of cell conjugate and HIV-induced syncytium
       formation.
 DE    alpha-Glucosidases/*ANTAGONISTS & INHIB  Animal  Antibodies, Monoclonal
       Antigens, CD/*BIOSYNTHESIS/DRUG EFFECTS  Antigens, CD18/*BIOSYNTHESIS
       Binding Sites, Antibody  Cells, Cultured  Gene Expression/DRUG EFFECTS
       Human  Indolizines/*PHARMACOLOGY  Interleukin-2/PHARMACOLOGY  Lymphocyte
       Culture Test, Mixed  Lymphocyte Function-Associated
       Antigen-1/*ANALYSIS/*BIOSYNTHESIS/  IMMUNOLOGY  Lymphocyte
       Transformation  Lymphocyte Transfusion  Lymphocytes/DRUG
       EFFECTS/*IMMUNOLOGY  Mice  Mice, SCID  Recombinant Proteins/PHARMACOLOGY
       Transplantation, Heterologous  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).