Document 0135
 DOCN  M9590135
 TI    Disseminated Mycobacterium genavense infection in Canadian AIDS
       patients.
 DT    9509
 AU    Shafran SD; Taylor GD; Talbot JA; Department of Medicine, University of
       Alberta, Edmonton, Canada.
 SO    Tuber Lung Dis. 1995 Apr;76(2):168-70. Unique Identifier : AIDSLINE
       MED/95299096
 AB    Mycobacterium genavense is a recently described mycobacterial species
       which thus far has been identified only in persons with advanced HIV
       disease. It appears to be a rare pathogen with an undefined reservoir.
       We describe the first two cases of M. genavense infection in Canadian
       AIDS patients. The clinical presentation of fever and wasting with
       extremely low CD4 lymphocyte counts was indistinguishable from
       disseminated M. avium complex (MAC) infection. However, blood cultures
       in BACTEC 13A medium required a mean of 58 days (range 41-87) to detect
       growth of M. genavense in contrast to a mean of 10 days for MAC in our
       laboratory. M. genavense infection is underdiagnosed due to the lack of
       universal use of BACTEC liquid medium and the use of relatively short
       incubation times (only 6 weeks) by some laboratories. The value of
       antimycobacterial therapy for M. genavense is unknown, but anecdotal
       data suggest that treatment with a regimen appropriate for MAC may be
       beneficial.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Case Report
       Human  Male  Mycobacterium Infections,
       Atypical/*COMPLICATIONS/MICROBIOLOGY  JOURNAL ARTICLE

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