Document 0158
 DOCN  M9590158
 TI    Temporal changes in the sensitivity of Neisseria gonorrhoeae to
       penicillin in Edinburgh, Scotland.
 DT    9509
 AU    Ross JD; Moyes A; McMillan A; Young H; Department of Genitourinary
       Medicine, Edinburgh Royal Infirmary,; UK.
 SO    Int J STD AIDS. 1995 Mar-Apr;6(2):110-3. Unique Identifier : AIDSLINE
       MED/95298891
 AB    Increased resistance of Neisseria gonorrhoeae to penicillin has been
       reported from many centres around the world since the introduction of
       antibiotic therapy in the 1940s. This study reports the temporal changes
       in gonococcal penicillin sensitivity over a 3-year period. All patients
       with a diagnosis of gonorrhoea in the city of Edinburgh, Scotland
       between 1990 and 1992 were included in the study. Penicillin sensitivity
       of isolates was analysed in relation to the sex and sexual orientation
       of the patient and the antibiotic therapy given. Four hundred and
       twenty-seven new patient episodes of infection occurred of which
       penicillin sensitivities were available in 426. Eleven episodes of PPNG
       infection occurred. Chromosomally mediated penicillin resistance did not
       increase over the study period. No differences were evident in the
       sensitivity of isolates from homosexual and heterosexual patients.
       Unlike many other areas the relative resistance of N. gonorrhoeae is not
       increasing in Edinburgh at present. This may relate to local antibiotic
       policies combined with intrinsic characteristics of N. gonorrhoeae
       itself. Unlike previous reports there did not appear to be any increased
       resistance to penicillin in isolates from gay men.
 DE    Female  Gonorrhea/*DRUG THERAPY  Human  Male  Neisseria
       gonorrhoeae/*DRUG EFFECTS  *Penicillin Resistance
       Penicillins/*THERAPEUTIC USE  Scotland  Sex Behavior  Time Factors
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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