Document 0160
 DOCN  M9590160
 TI    Markers of past syphilis in HIV infection comparing Captia Syphilis G
       anti-treponemal IgG enzyme immunoassay with other treponemal antigen
       tests.
 DT    9509
 AU    Young H; Moyes A; Ross JD; STD Diagnostic Reference Laboratory,
       Department of Medical; Microbiology, Edinburgh University Medical
       School, UK.
 SO    Int J STD AIDS. 1995 Mar-Apr;6(2):101-4. Unique Identifier : AIDSLINE
       MED/95298889
 AB    The sensitivity of the Captia Syphilis G anti-treponemal IgG enzyme
       immunoassay (EIA-IgG) was compared with the Treponema pallidum
       haemagglutination assay (TPHA) and the Fluorescent Treponemal Antibody
       Absorbed (FTA-Abs) test as a marker for past syphilis in 28 HIV-infected
       and 31 HIV-negative patients with a past history of syphilis. The
       specificity of EIA-IgG was compared in 89 patients without a history of
       syphilis who were known to be HIV antibody positive with a control group
       of 89 patients who had tested HIV negative. In patients with a past
       history of syphilis each treponemal test (EIA-IgG, TPHA and FTA-Abs)
       gave a lower sensitivity (82%, 86%, 79%) in the HIV-positive group than
       in the HIV-negative group (97%) but the difference was significant only
       in the case of the FTA-Abs test (P < 0.05). In the HIV-positive patients
       11% (3/28) were negative in all 3 treponemal tests while 25% (7/28) were
       negative in at least one treponemal test. In patients without a past
       history of syphilis the EIA-IgG antibody index in the HIV-positive group
       (0.436) was significantly higher than in the HIV-negative group (0.378):
       the specificity, however, was similar in the HIV-positive (100%) and
       HIV-negative group (99%). We conclude that the Captia Syphilis G
       anti-treponemal IgG enzyme immunoassay is of similar specificity in
       HIV-positive and HIV-negative patients and is of similar sensitivity to
       the TPHA and FTA-Abs as a marker of past syphilis in HIV-infected
       patients.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Antibodies, Bacterial/*BLOOD  Biological Markers/ANALYSIS  Comparative
       Study  Fluorescent Antibody Technique  Hemagglutination Tests  Human
       HIV Infections/*COMPLICATIONS  Immunoenzyme Techniques  Sensitivity and
       Specificity  Syphilis/COMPLICATIONS/*IMMUNOLOGY/MICROBIOLOGY  Syphilis
       Serodiagnosis/*METHODS  Treponema pallidum/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).