Document 0172
 DOCN  M9590172
 TI    Relationship of trace element, immunological markers, and HIV1 infection
       progression.
 DT    9509
 AU    Allavena C; Dousset B; May T; Dubois F; Canton P; Belleville F; Clinical
       Biochemistry Department CHRU Nancy.
 SO    Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):133-8. Unique Identifier :
       AIDSLINE MED/95298485
 AB    Trace elements (selenium, zinc, copper), beta 2 microglobulin levels,
       CD4, and CD8 cell counts have been determined in 80 HIV1 seropositive
       patients. The study group consisted of 19 females and 61 males with age
       mean of 35 +/- 10 yr, at stage IV of infection (CDC--Atlanta
       classification) and treated by AZT. No severe renal or liver diseases or
       hypoalbuminemia were observed in this group. Se values were
       significantly lower than in normal adults, 48.3 +/- 17 micrograms/L vs
       71 +/- 12 micrograms/L; Zn was moderately diminished, 1 +/- 0.2 mg/L vs
       1.2 +/- 0.2 mg/L, whereas copper values were in the normal range, 1.2
       +/- 0.3 mg/L vs 1.1 +/- 0.5 mg/L. Se or Zn deficiency was found in 60
       and 30 subjects, respectively. Blood Se and Zn decreases were associated
       in 23 patients. Moreover, all patients showed higher beta 2
       microglobulin values than the upper normal limit of 2.4 mg/L. Negative
       correlations were found between Zn and beta 2 microglobulin (p < 0.005)
       and between Se and beta 2 microglobulin (p < 0.05). Moreover, there was
       a positive correlation between Se and Zn values (p < 0.05). Nineteen
       subjects died 1 yr later (group I), and 61 remained alive (group II).
       With respect to the clinical evolution, a significant difference between
       both groups was found in Se and beta 2 microglobulin levels as well as
       in CD4 cell counts. The correlations previously observed persisted in
       group II, whereas no correlation was noted in group I. In addition, the
       patients of group one had significantly lower Se values, which were
       below 30 micrograms/L in 10 cases.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/EPIDEMIOLOGY/*PHYSIOPATHOLOGY  Comparative Study  Copper/BLOOD
       CD4 Lymphocyte Count  CD8-Positive T-Lymphocytes  Disease Progression
       Female  Follow-Up Studies  Human  HIV
       Seropositivity/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY  *HIV-1  Lymphocyte
       Count  Male  Prognosis  Risk Factors  Selenium/BLOOD  Time Factors
       Trace Elements/*BLOOD  Zinc/BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).