Document 0189
 DOCN  M9590189
 TI    Towards the ideal clinical trial: a participant's perspective.
 DT    9509
 AU    Duffin R; AIDS Council of NSW.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:87 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291910
 AB    People with HIV have faced the task of trying to make meaning of
       clinical trials, what they mean and understanding quite complex
       decisions they face. The enthusiasm for participating in trials has
       changed. There is now less expectation of rapid advances in HIV
       medicine. More people have experienced clinical trials and are more
       aware of what participation means. Recruitment of trial participants is
       becoming a world wide problem, and if this is to be tackled it requires
       the active involvement of people with HIV and trials which are relevant
       to the local environment where they are conducted. The results of ten
       years experience have not only changed community expectations, but have
       led to a debate about appropriate trialing strategies and radically
       different approaches at a national level. Much of clinical trial design
       focuses on ensuring the removal of bias by either the participant or the
       researcher. Many other possible sources of bias such as the interface
       between trial sponsors and clinicians do not receive the same scrutiny.
       There are many areas where the trial mechanisms within Australia could
       be reviewed--particularly whether adequate resources exist at this point
       in the epidemic. However, the benefits to the morale of people with HIV
       of having effective clinical trials conducted within Australia cannot be
       understated.
 DE    Australia  Bias (Epidemiology)  Clinical Trials/*STATISTICS & NUMER DATA
       Human  HIV Infections/*DRUG THERAPY/PSYCHOLOGY  Patient Satisfaction
       Patient Selection  Sick Role  Treatment Outcome  MEETING ABSTRACT

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