Document 0191
 DOCN  M9590191
 TI    The effect of HIV on macrophage function.
 DT    9509
 AU    Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield;
       Hospital, Vic.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:84 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291908
 AB    Macrophages provide critical functions within the immune system,
       including chemotaxis, phagocytosis and killing of microbes, antigen
       presentation, cytokine production and tumour surveillance. The published
       literature does not consistently demonstrate abnormal function of cells
       of macrophage lineage following their infection with HIV. This is due at
       least in part to differing methodologies, particularly due to
       difficulties in interpretation of data following testing of cells from
       HIV infected persons, rather than using cells from seronegative
       individuals infected in vitro. Using the latter approach we have found
       impaired phagocytosis of Candida albicans by macrophages infected in
       vitro with the Ba-L strain of HIV. In addition, receptor-mediated uptake
       of opsonized Toxoplasma gondii is less efficient in HIV-infected
       macrophages when compared with uninfected cells from the same donor,
       although active invasion of the parasite is not altered by HIV infection
       of macrophages. Killing of Toxoplasma gondii is also reduced in the
       infected cells, but is modestly restored by gamma-interferon. Our
       findings may provide an explanation for reactivation of certain
       opportunistic infections in persons with advanced HIV infection.
 DE    Animal  AIDS-Related Opportunistic Infections/IMMUNOLOGY  Candida
       albicans/IMMUNOLOGY  Human  HIV/*IMMUNOLOGY/PATHOGENICITY  HIV
       Infections/*IMMUNOLOGY  Macrophages/*IMMUNOLOGY/VIROLOGY
       Phagocytosis/IMMUNOLOGY  Toxoplasma/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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