Document 0202
 DOCN  M9590202
 TI    Clinical manifestations of human immunodeficiency virus (HIV-1)
       infection in Australian children infected during the neonatal period.
 DT    9509
 AU    Cruickshank M; Ziegler JB; Hughes C; Paediatric AIDS Unit, Prince of
       Wales Children's Hospital,; Randwick NSW.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:67 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291897
 AB    AIM: To describe the clinical manifestations of human immunodeficiency
       virus (HIV-1) infection in Australian children infected during the
       neonatal period. METHOD: A retrospective review of children infected
       with HIV as neonates who were referred to the Paediatric AIDS Unit.
       RESULTS: 25 children were identified as infected with HIV infection in
       the neonatal period. 4 were infected as the result of the transfusion of
       blood products in the neonatal period and 21 were infected by perinatal
       transmission. Age at diagnosis varied from 6 weeks to 5 years. Ten child
       in this group have died as the result of an AIDS-related illness (age
       range 3 months to 9 years). Symptoms of HIV infection were noted in 7
       children before the age of one year, in 4 children by the age of 3
       years; 6 children by the age of 5 years. 2 of these children have had an
       AIDS-defining illness. 8 children remain asymptomatic. CONCLUSION: The
       manifestations of HIV in children infected during the neonatal period
       appears to display a bi-modal picture with some children becoming
       symptomatic in infancy with a shorted life span, while others appear to
       follow the adult model with many years of asymptomatic infection.
 DE    AIDS-Related Opportunistic Infections/DIAGNOSIS/TRANSMISSION  Blood
       Component Transfusion  Child  Child, Preschool  Disease Transmission,
       Horizontal  Disease Transmission, Vertical  Female  Follow-Up Studies
       Human  HIV Infections/*CONGENITAL/DIAGNOSIS/TRANSMISSION  *HIV-1  Infant
       Infant, Newborn  Male  Retrospective Studies  Risk Factors  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).