Document 0259
 DOCN  M9590259
 TI    The effect of the anabolic steroid, nandrolone decanoate, on lean body
       mass and quality of life in HIV+ men--a preliminary analysis.
 DT    9509
 AU    Gold J; High H; Michelmore H; Oliver C; Albion Street Centre, Surry
       Hills, Sydney.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:264 (unnumbered poster).
       Unique Identifier : AIDSLINE ASHM6/95291840
 AB    INTRODUCTION: Unexplained loss of lean body mass in HIV disease is
       common, particularly in the late stage, and contributes to reduced
       quality of life and survival time. This trend might be stabilised or
       reversed for a time with anabolic steroids and resitive exercise.
       METHOD: Patients who had lost 5-15% of their usual body weight were
       nutritionally counselled. Those who were not able to gain weight or who
       were unable to maintain any weight gained for 4 weeks were enrolled into
       this pilot study combining resistive exercise with nandrolone decanoate
       100mg IMI every 2 weeks, for 16 weeks. Weight, lean body mass, quality
       of life, food intake and laboratory parameters were measured before and
       during the study. This abstract is a preliminary report on 11 subjects
       who completed the first 8 weeks of the study. Final data on subjects
       will also be presented. RESULTS: Overall there was a nett increase of
       1.8kg +/- 1.9kg over the 8 week period (range 1.6kg to 3.8kg). This
       increase was predominantly lean body mass with mid arm muscle areas (a
       measure of somatic protein stores) increasing by 351 +/- 473 mm2 with no
       nett change in arm fat area. There was a nett increase in quality of
       life, as measured by the MOS SF30 questionnaire, with the largest
       improvements in the scales measuring vigorous activity/fatigue, positive
       affect and health distress. There were no significant changes to CD4+
       cells, predominantly because the majority of the sample was already
       severely immunosupressed (average CD4+ cells 130). There was however, a
       trend towards increasing CD4+ numbers in subjects with initial numbers >
       350.
 DE    Anabolic Steroids/*ADMINISTRATION & DOSAGE  *Body Mass Index  Body
       Weight/DRUG EFFECTS  Combined Modality Therapy  Exercise  Human  HIV
       Seropositivity/*DRUG THERAPY  Male  Muscle, Skeletal/DRUG EFFECTS
       Nandrolone/*ANALOGS & DERIVATIVES/ADMINISTRATION & DOSAGE  Physical
       Endurance/DRUG EFFECTS  Pilot Projects  *Quality of Life  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).