Document 0260
 DOCN  M9590260
 TI    Comparison of the operational effectiveness of general practice versus
       hospital sites in a phase II HIV clinical trial.
 DT    9509
 AU    Hales G; Beveridge A; Anderson J; Mitchell J; Schreurs E; Smith D;
       CHATN, Darlinghurst.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:263 (unnumbered poster).
       Unique Identifier : AIDSLINE ASHM6/95291839
 AB    OBJECTS: Data on Australian recruitment rates was examined to compare
       the operational effectiveness of General Practice sites versus hospital
       sites in an intensive phase II clinical trial. METHODS: The trial
       required 150 participants to attend trial sites at least monthly. The
       visits required clinical assessment, collection of blood samples before
       noon for complex assays, IM drug administration and monitoring for one
       hour post therapy. Effectiveness was determined by the time taken to
       recruit the target number. All sites were coordinated through CHATN with
       equal provision of research nurse time and other support. RESULTS: 2
       hospitals and 8 GP sites were activated, 153 patients have been enrolled
       to date. TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSIONS: GP sites were
       as effective as hospital sites in enrolling eligible patients as
       hospital sites in this trial. The strength of the individual
       doctor-patient relationship in general practice may have been one of the
       factors which facilitated this. GP sites should therefore be considered
       as effective venues for future HIV clinical trials.
 DE    Antiviral Agents/*THERAPEUTIC USE  Australia  Comparative Study  *Family
       Practice  Human  HIV Infections/*DRUG THERAPY  Injections, Intramuscular
       *Outpatient Clinics, Hospital  Patient Selection  Treatment Outcome
       CLINICAL TRIAL  CLINICAL TRIAL, PHASE II  MEETING ABSTRACT

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