Document 0261
 DOCN  M9590261
 TI    Death from encephalitis within one week of proven HIV sero conversion
       illness onset.
 DT    9509
 AU    England JD; Liang T; Leicester J; Cunningham A; Lawrence C; Blue
       Mountains Hospital, Katoomba.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:262 (unnumbered poster).
       Unique Identifier : AIDSLINE ASHM6/95291838
 AB    A 23 year old male previously known to be HIV negative three months
       prior developed an acute glandular fever like illness and raised liver
       enzymes. He was known to have a proven EB virus illness five years
       prior. His presenting symptom was painful pharyngitis and inability to
       tolerate oral antibiotics. Two days later he was admitted with
       persistent fever and vomiting and given i.v. fluids and crystalline
       Penicillin G. He developed confusion and aggressive behaviour towards
       his family. A L.P. showed two white cells per high power field and
       raised CSF protein 1.6 g/l. Over a space of eight hours he developed
       signs of cerebral irritability culminating in an increasing frequency of
       grand mal seizures unresponsive to Diazepam and Diphenyl Hydantoin. A CT
       scan showed diffuse cerebral oedema. Despite all attempts at assisted
       ventilation he died 24 hours later. His serology results 48 hours before
       death showed weakly positive HIV Antibody, P24 Antigen EIA positive. HIV
       Western Blot Negative. Post mortem showed cerebral oedema. HIV
       polymerase chain reaction revealed the virus only in the cervical lymph
       nodes. All other viral studies were negative. His male partner two weeks
       later developed headaches and a mild encephalitis like illness with
       raised CSF protein. The partner's history and serology suggested an HIV
       illness of 12 months.
 DE    Adult  AIDS-Related Opportunistic Infections/IMMUNOLOGY/*PATHOLOGY
       Brain/PATHOLOGY  Brain Edema/IMMUNOLOGY/PATHOLOGY  Case Report
       Encephalitis, Viral/IMMUNOLOGY/*PATHOLOGY  Fatal Outcome  *Herpesvirus
       4, Human/IMMUNOLOGY  Human  HIV Seropositivity/IMMUNOLOGY/*PATHOLOGY
       Infectious Mononucleosis/IMMUNOLOGY/*PATHOLOGY  Lymph Nodes/PATHOLOGY
       Male  MEETING ABSTRACT

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