Document 0270
 DOCN  M9590270
 TI    CD40L has potent antiviral activity.
 DT    9509
 AU    Ruby J; Ramshaw I; Viral Engineering Group, JCSMR, Canberra.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:252 (unnumbered poster).
       Unique Identifier : AIDSLINE ASHM6/95291829
 AB    Signalling of B cells via the constitutively expressed CD40 molecule is
       an essential component of the T cell help required for an antibody
       response. The ligand for CD40 (CD40L or gp39) has been recently cloned
       and shown to be transiently induced on the surface of T cells as a
       consequence of antigen recognition. The interaction between CD40 and its
       ligand, in the presence of B cell acting cytokines, such as interleukin
       4 (IL-4), is sufficient to trigger B cells to proliferate and
       differentiate and to induce immunoglobulin class switching. A
       recombinant vaccinia virus encoding both factors, CD40L and IL-4, did
       not, however, stimulate an enhanced antibody response in mice infected
       with the construct. Instead, the antibody levels were lower than those
       of mice infected with a control virus. The reduced antibody response
       reflected the diminished growth of CD40L-expressing viruses, to the
       extent that immunocompromised mice were able to resolve these
       infections. The kinetics of virus clearance indicate that the anti-viral
       mechanism of CD40L is rapidly activated. The generalized tissue
       distribution of this phenomenon, even in mice lacking B cells, suggests
       that the receptor involved in the anti-viral activity of CD40L is
       unlikely to be CD40. The anti-viral activity of CD40L may represent a
       surprising and potent effector mechanism of T cells activated during a
       virus infection.
 DE    Animal  Antigens, CD/GENETICS/*IMMUNOLOGY  Antigens, Differentiation,
       B-Lymphocyte/GENETICS/*IMMUNOLOGY  B-Lymphocytes/*IMMUNOLOGY  Gene
       Expression Regulation, Viral/IMMUNOLOGY  Immune
       Tolerance/GENETICS/IMMUNOLOGY  Interleukin-4/GENETICS/PHYSIOLOGY
       Lymphocyte Transformation/GENETICS/IMMUNOLOGY  Mice
       T-Lymphocytes/*IMMUNOLOGY  Vaccinia Virus/GENETICS/*IMMUNOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).