Document 0278
 DOCN  M9590278
 TI    Presence of HIV-1 neutralising antibodies in sera from a panel of
       asymptomatic individuals.
 DT    9509
 AU    Chatfield C; Learmont J; McPhee D; Macfarlane Burnet Centre for Medical
       Research, Fairfield,; Victoria, Australia.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:244 (unnumbered poster).
       Unique Identifier : AIDSLINE ASHM6/95291821
 AB    Several patients received HIV-1 contaminated whole blood or red blood
       cells from a common donor between Jan. 1982 and June 1984. One of these
       recipients received a triple washed preparation and is HIV negative,
       another recipient died due to SLE. The six remaining recipients and the
       donor remain clinically free of symptoms with normal CD4 counts and no
       p24 antigenaenia after 10 to 13 years (Learmont et al, 1992). We have
       investigated the role of neutralising antibodies in inhibiting HIV-1
       infection in these patients. Sera from each of these recipients and the
       donor, were tested for the presence of neutralising antibodies against
       C18. Sera from only two of these individuals, the donor and C18, showed
       almost total viral inhibition (97% and 98.4% inhibition respectively) at
       an antibody dilution of 1/25. Of the remaining sera three inhibit viral
       production by more than 50%, while the remaining two sera inhibited
       virus replication by less than 50%. HIV negative sera.inhibited virus
       replication by 14% to 48%. This data indicates that neutralising
       antibodies may not be responsible for the asymptomatic status of these
       individuals. However further testing against other isolates from this
       panel and reference strains will be required to assess the overall
       importance of neutralising antibodies in the maintainance of the
       asymptomatic state.
 DE    Blood Donors  Blood Transfusion  Follow-Up Studies  Human  HIV
       Antibodies/*BLOOD  HIV Seropositivity/*IMMUNOLOGY/TRANSMISSION
       HIV-1/*IMMUNOLOGY  *Neutralization Tests  MEETING ABSTRACT

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