Document 0287
 DOCN  M9590287
 TI    Cellular aspects of the pathogenesis of AIDS dementia.
 DT    9509
 AU    Pulliam L; University of California, San Francisco, USA.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:223 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291812
 AB    Several mechanisms have been hypothesized for the dementia associated
       with AIDS. They include neurotoxicity from the virus itself (eg. gp120,
       tat) or neurotoxic factors/cytokines produced from macrophages infected
       with HIV (eg. quinolinic acid, TNF alpha, IL-6). Our laboratory has been
       interested in several of these mechanisms. Using a human brain cell
       aggregate model, we have shown that macrophages isolated from patients
       with and with out HIV dementia produced a neurotoxin as well as elevated
       levels of IL-6 and TNF alpha. Direct treatment of brain aggregates with
       these two cytokines did not result in the same neuropathology as that
       observed from treatment with HIV-infected macrophage soluble factors. In
       related studies, gp120 treatment of brain aggregates upregulated IL-6
       and TNF alpha and induced astrocyte death by apoptosis.
 DE    Apoptosis/IMMUNOLOGY  Astrocytes/IMMUNOLOGY  AIDS Dementia
       Complex/*IMMUNOLOGY  Brain/IMMUNOLOGY  Cells, Cultured  Human  HIV
       Envelope Protein gp120/PHYSIOLOGY  HIV-1/IMMUNOLOGY
       Interleukin-6/METABOLISM  Macrophages/*IMMUNOLOGY
       Neurotoxins/*METABOLISM  Tumor Necrosis Factor/METABOLISM  Up-Regulation
       (Physiology)/PHYSIOLOGY  MEETING ABSTRACT

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