Document 0315
 DOCN  M9590315
 TI    The role of cytokines in immunity to murine retrovirus infection.
 DT    9509
 AU    Segal D; Ramsay A; Ruby J; Ramshaw I; Viral Engineering and Cytokine
       Group, John Curtin School of; Medical Research, ANU Canberra.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:188 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291784
 AB    Cytokines have been shown to play a crucial role in coordinating and
       mediating antiviral immune responses. Recently it has been postulated
       that inappropriate patterns of cytokine production during HIV infection
       may inhibit protective immune responses and result in progression to
       AIDS. To investigate this idea further we have used the murine
       retrovirus-Rauscher murine leukemia virus (R-MuLV) to investigate the
       role of cytokines in immunity to retrovirus infections. We have shown
       that R-MuLV infection markedly alters in vitro cytokine production by
       spleen cells from infected mice and that susceptibility correlates with
       decreased IFN-gamma and IL-2 production. This effect appears to be
       specific to the spleen as lymph node cells produce similar patterns of
       cytokines in vitro. Expression of cytokine genes in vivo is currently
       under investigation using RT-PCR to detect cytokine mRNA. Systemic
       administration of recombinant cytokines and cytokine neutralising
       monoclonal antibodies have also been used in an attempt to alter disease
       phenotype following R-MuLV infection.
 DE    Animal  Cytokines/*PHYSIOLOGY  Immune Tolerance/IMMUNOLOGY  Interferon
       Type II/PHYSIOLOGY  Interleukin-2/PHYSIOLOGY  Leukemia,
       Experimental/*IMMUNOLOGY/VIROLOGY  Mice  Rauscher Virus/*IMMUNOLOGY
       MEETING ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).