Document 0326
 DOCN  M9590326
 TI    Subjective cognitive dysfunction, mood and activities of daily living as
       indicators of HIV associated dementia complex.
 DT    9509
 AU    Maruff P; Malone V; Wright E; Tyler P; Hoy J; Brew B; Currie J;
       Fairfield Infectious Diseases Hospital, Mental Health Research;
       Institute of Victoria.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:174 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291773
 AB    OBJECTIVE: To examine the effect of HIV associated dementia complex
       (HDC) on activities of daily living, mood and self perceived cognitive
       dysfunction. METHODS: Patients with CD4 cells < 250 mm-3 were recruited
       through large metropolitan hospital inpatient and outpatient departments
       and general practitioners' clinics. Patients rated the presence and
       severity of perceived problems with sleep, fatigue, motor, sensory,
       postural, perceptual or spatial-orientation functions, language, memory
       and concentration, activities of daily living (ADL) and anxiety and
       depression levels. To identify patients with HDC, extensive
       neurocognitive and psychiatric assessments were then performed, together
       with review of case records, laboratory test results and radiological
       examinations. Patients who met the criteria for HIV associated minor
       cognitive disorder were excluded. RESULTS: Of the 41 patients assessed
       all were living at home. 22 patients had probable HDC and 19 were
       classified as NI-HIV. There were no significant differences between the
       two subject groups for measures of CD4 cell count, age or education. HDC
       patients had significantly lower global ADL scores and difficulty in the
       areas of meal preparation, housework and medication but not transport,
       shopping or laundry. Self perceived problems were frequent in both
       subject groups, although significantly more HDC subjects reported
       changes in language, fatigue and concentration. In NI-HIV subjects, the
       number of areas in which there were self perceived problems correlated
       with depression but not anxiety or ADL scores. In HDC subjects the
       number of areas in which there were self perceived problems was not
       correlated with depression or anxiety levels but was correlated with ADL
       scores. CONCLUSION: Patients with CD4 cells below 250mm-3 who report
       self perceived problems with functional, cognitive or ADL activities
       should be investigated for HDC.
 DE    Activities of Daily Living/*PSYCHOLOGY  Affective
       Symptoms/*DIAGNOSIS/PSYCHOLOGY  AIDS Dementia
       Complex/*DIAGNOSIS/PSYCHOLOGY  CD4 Lymphocyte Count  Human
       *Neuropsychological Tests  Personality Assessment  *Sick Role  MEETING
       ABSTRACT

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