Document 0327
 DOCN  M9590327
 TI    Neuropsychological characterization of the HIV associated dementia
       complex.
 DT    9509
 AU    Maruff P; Tyler P; Malone V; Wright E; Hoy J; Brew B; Currie J;
       Fairfield Infectious Diseases Hospital, Mental Health Research;
       Institute of Victoria.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:173 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291772
 AB    OBJECTIVE: To investigate the neuropsychological deficits present in
       mild HIV associated dementia complex (HDC). METHOD: Subjects recruited
       from large metropolitan hospital out-patient clinics; all living
       independently in the general community. A comprehensive
       neuropsychological test battery was administered to 3 volunteer samples
       of homosexual/bisexual males; (i) 35 patients who met clinical and
       research criteria for probable mild HDC, (Price Brew rating scale = 1 or
       2) (ii) 27 HIV seronegative (HIV-) controls, (iii) 27 neurologically
       intact AIDS (NI-AIDS) patients, matched with the HDC subjects by CD4
       lymphocyte count for severity of systemic HIV disease. RESULTS: Compared
       with NI-AIDS patients, stage 1 HDC patients performed significantly
       worse in the cognitive domains of executive function, memory and complex
       attention, but not in affect or the cognitive domains of simple motor
       function, orientation, language, or visuospatial construction. Patients
       with stage 2 HDC showed poor performance for the same domains as in
       stage 1 but in addition had impairment in simple motor function and
       language. Within the domains of executive function, memory and complex
       attention, test performance was impaired in a maximum of only one domain
       in all of the HIV(-) controls and 95% of the NI-AIDS subjects. In marked
       contrast, 34 (97%) of the 35 mild ADC patients had abnormal test
       performance in all three of these cognitive domains. CONCLUSION: This
       pattern of neuropsychological deficits in mild ADC is suggestive of a
       subcortical dementia.
 DE    AIDS Dementia Complex/CLASSIFICATION/*DIAGNOSIS/PSYCHOLOGY  AIDS
       Serodiagnosis  Bisexuality/PSYCHOLOGY  Homosexuality, Male/PSYCHOLOGY
       Human  HIV Infections/CLASSIFICATION/DIAGNOSIS/PSYCHOLOGY  Male
       *Neuropsychological Tests/STATISTICS & NUMER DATA  Psychometrics
       Reference Values  MEETING ABSTRACT

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