Document 0328
 DOCN  M9590328
 TI    Clinical predictors of the presence of dementia and neuropsychological
       impairment in HIV infection.
 DT    9509
 AU    Dunbar N; Pemberton L; Perdices M; Brew B; National Centre for
       Epidemiology and Clinical Research,; University of New South Wales,
       Sydney.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:172 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291771
 AB    OBJECTIVES: To investigate the ability of clinical, laboratory and
       demographic variables to predict the presence of dementia and
       neuropsychological impairment in patients with CD4 count < 200.
       METHODOLOGY: 50 HIV- and 59 HIV+ subjects were assessed neurologically
       and neuropsychologically, and a subset of subjects underwent lumbar
       punctures. Logistic regression was used to determine which variables
       from a set including age, education, IQ, depression, anxiety, CD4 cell
       counts, haemoglobin, serum and CSF beta 2 microglobulin and neopterin,
       constitutional symptoms, past opportunistic infections and use of
       antiretroviral therapy predicted the occurrence of dementia according to
       the ADC rating scale, and cognitive impairment according to four
       criteria of neuropsychological abnormality. RESULTS: An increased
       likelihood of neurological and neuropsychological dysfunction was
       associated with a history of weight loss six months prior to assessment,
       diarrhoea at some time in the recent past, and a high level of serum
       neopterin at the time of assessment. A decreased likelihood of
       impairment was associated with a higher estimated IQ, more years of
       education, and use of zidovudine, but not ddI, for longer than two
       months at the time of assessment. CONCLUSION: The results support a
       model of increased cytokine production causing systemic and cerebral
       damage, and provide a simple clinical method for screening for the
       presence of ADC.
 DE    AIDS Dementia Complex/*DIAGNOSIS/IMMUNOLOGY/PSYCHOLOGY  AIDS
       Serodiagnosis  AIDS-Related Opportunistic
       Infections/DIAGNOSIS/IMMUNOLOGY/  PSYCHOLOGY  Biopterin/ANALOGS &
       DERIVATIVES/BLOOD  CD4 Lymphocyte Count  Human  HIV
       Seropositivity/DIAGNOSIS/IMMUNOLOGY/PSYCHOLOGY  Neurologic Examination
       *Neuropsychological Tests  Risk Factors  Zidovudine/ADVERSE
       EFFECTS/THERAPEUTIC USE  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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