Document 0334
 DOCN  M9590334
 TI    Decay of transplacental human immunodeficiency virus type-1 (HIV-1)
       antibodies in neonates and infants.
 DT    9509
 AU    Palasanthiran P; Robertson P; Graham GG; Hughes C; Ziegler JB; Prince of
       Wales Children's Hospital, Randwick NSW, Australia.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:165 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291765
 AB    Transplacental human immunodeficiency virus (HIV) antibodies from 11
       uninfected and 3 infected infants of HIV seropositive mothers were
       quantitated using end point titration of twofold dilutions of sera by a
       particle-agglutination method (Serodia). 4 or more sequential sera from
       each infant collected between birth and age 14 months or more were
       analysed. Linear regression of log2 antibody titres of the uninfected
       infants plotted against age (days) demonstrated an exponential decay in
       maternal HIV antibodies. The mean half life of passive HIV antibodies
       was 23.1 +/- s.d 4.2 days, range 18.2 to 29.3 days (95% confidence
       interval [CI]: 20.2 to 26.0 days). The median age of clearance of
       maternal HIV antibodies was 13.3 months (range 10.4 to 15.6 months). A
       model assuming first order exponential decay and production of HIV
       antibodies was fitted to the time course of antibody titres of the
       infected infants. Minimal titres in each infected infant occurred at
       5.5, 4.9 and 4.0 months and doubling times of HIV antibodies from that
       point ranged from 16.8 days to 31.4 days. CONCLUSION: In infants at risk
       of perinatal transmission of HIV, maternal HIV antibody decays with a
       half-life of approximately 3 weeks in the first 6 months after birth.
       Exponential decline in HIV antibody levels appears to proceed at a
       similar rate in uninfected and infected infants.
 DE    AIDS Serodiagnosis  Disease Transmission, Vertical  Female  Follow-Up
       Studies  Half-Life  Human  HIV Antibodies/*BLOOD  HIV
       Infections/DIAGNOSIS/IMMUNOLOGY/*TRANSMISSION  HIV-1/*IMMUNOLOGY  Infant
       Infant, Newborn  Maternal-Fetal Exchange/*IMMUNOLOGY
       Placenta/*IMMUNOLOGY  Pregnancy  Risk Factors  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).