Document 0373
 DOCN  M9590373
 TI    Evaluation of results and clinical utility of bone marrow examination in
       patients with HIV.
 DT    9509
 AU    Torda A; Jones PD; Beale P; Department of Infectious Diseases, Prince
       Henry Hospital, Little; Bay, NSW.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:117 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291726
 AB    AIM: To examine the experience at this hospital of bone marrow (BM)
       examinations in patients with HIV and assess the clinical indications
       for which this procedure had the highest yield. METHODS: Case records of
       forty patients who had a total of fifty-one BM examinations between
       January 1993 and February 1994 were reviewed. RESULTS: BM aspirates were
       usually non-specific. Dysplasia and hypercellularity were the most
       common findings. Specific features were present in 48% of the BM
       trephines. Apart from lymphoma staging, the diagnosis of mycobacterial
       (MAC) infection, based on the presence of granulomata +/- acid fast
       bacteria (AFB's) and mycobacterial culture was the most common specific
       result. The BM examination had an impact on clinical management in 49%
       of cases overall. When BM results were matched with the documented
       indication for the procedure, clinical suspicion of MAC infection had
       the highest specific yield (63%) and anaemia alone, the lowest specific
       yield (28%). CONCLUSION: The effects of HIV on haematopoiesis are
       profound and common in late stage HIV. Other factors affecting the BM
       include drugs, opportunistic infections and malignancies. This review of
       BM examinations in patients with HIV/AIDS has shown it to be helpful in
       almost 50%, particularly for lymphoma staging or when disseminated MAC
       infection is clinically suspected.
 DE    AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY  Bone
       Marrow/PATHOLOGY  *Bone Marrow Examination  Diagnosis, Differential
       Human  HIV Infections/*DIAGNOSIS/PATHOLOGY  Lymphoma,
       AIDS-Related/*DIAGNOSIS/PATHOLOGY  Mycobacterium
       Infections/*DIAGNOSIS/PATHOLOGY  MEETING ABSTRACT

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