Document 0374
 DOCN  M9590374
 TI    Hypopyon panuveitis in patients with AIDS.
 DT    9509
 AU    McCluskey PJ; Hykin P; Pavesio CE; Towler HM; Lightman S; Department of
       Clinical Ophthalmology, Moorfields Eye Hospital,; London, England.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:116 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291725
 AB    OBJECTIVE: to describe the clinical and microbiological features of a
       group of five patients with AIDS presenting with 13 episodes of acute
       endophthalmitis possibly associated with the use of rifabutin. DESIGN: A
       retrospective review of medical records and a series of polymerase chain
       reactions using stored aqueous and vitreous samples. SETTING AND
       PATIENTS: Patients referred to the Department of Clinical Ophthalmology
       for management. The study was undertaken at the Institute of
       Ophthalmology and Moorfields Eye Hospital London. RESULTS: All involved
       eyes made an excellent response to therapy with broad spectrum
       intravitreal anti microbial agents, intensive topical corticosteroids
       and subconjunctival mydriatics. All patients continued all systemic
       medications including rifabutin. All microbiological investigations were
       negative. CONCLUSIONS: These five patients with severe hypopyon
       panuveitis are a previously unrecognised group of patients with uveitis
       associated with rifabutin therapy.
 DE    Acquired Immunodeficiency Syndrome/DIAGNOSIS/*DRUG THERAPY  AIDS-Related
       Opportunistic Infections/DIAGNOSIS  Diagnosis, Differential
       Endophthalmitis/*CHEMICALLY INDUCED/DIAGNOSIS  Human
       Panuveitis/*CHEMICALLY INDUCED/DIAGNOSIS  Retrospective Studies
       Rifabutin/*ADVERSE EFFECTS/THERAPEUTIC USE  MEETING ABSTRACT

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