Document 0376
 DOCN  M9590376
 TI    Intestinal microsporidiosis due to Septata intestinalis in nine
       HIV-infected patients.
 DT    9509
 AU    Dore GJ; Field AS; Marriott DJ; Hing MC; Verre J; Harkness JL;
       Department of Microbiology, St. Vincent's Hospital, Sydney.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:114 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291723
 AB    OBJECTIVE: To describe the clinical and pathological features of
       disseminated microsporidiosis due to the newly described species Septata
       intestinalis in nine HIV-infected patients. METHODS: Intestinal
       microsporidiosis was diagnosed by modified trichrome or uvitex 2B stain
       of faecal specimens and Warthin-Starry staining of endoscopic duodenal
       biopsies. S. Intestinalis duodenal infection was confirmed by electron
       microscopy and evidence of dissemination sought by examination of urine,
       sputum and nasal washings and/or biopsy specimens. RESULTS: All nine
       patients were male homosexuals with a mean age of 41 years (range
       35-58). They were all severely immunocompromised with a mean CD4
       T-lymphocyte count of 15/ul (range 0-32). Infection by S. intestinalis
       was demonstrated in duodenal biopsy specimens in all patients and
       dissemination was shown by the presence of microsporidial spores in
       urine (9/9), nasal washings and/or biopsies (6/6) and sputum (6/6).
       Seven patients were treated with albendazole 400mg bd orally, with
       significant improvement or complete resolution of diarrhoea in six, and
       improvement in symptoms in the five patients with chronic
       rhinosinusitis. There was a parallel parasitological response with
       clearance of S. intestinalis infection from almost all sites.
       CONCLUSION: S. intestinalis infection affects severely immunocompromised
       HIV-infected patients and has been shown to be widely disseminated. It
       has a favourable clinical and parasitological response to albendazole
       therapy.
 DE    Adult  AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY
       Enteritis/*DIAGNOSIS/PATHOLOGY  Feces/PARASITOLOGY  Homosexuality, Male
       Human  Intestinal Mucosa/PATHOLOGY  Male  Microspora
       Infections/*DIAGNOSIS/PATHOLOGY  Middle Age  MEETING ABSTRACT

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