Document 0396
 DOCN  M9590396
 TI    The vasculopathy of varicella-zoster virus encephalitis.
 DT    9509
 AU    Amlie-Lefond C; Kleinschmidt-DeMasters BK; Mahalingam R; Davis LE;
       Gilden DH; Department of Neurology, University of Colorado Health
       Sciences; Center, Denver 80262, USA.
 SO    Ann Neurol. 1995 Jun;37(6):784-90. Unique Identifier : AIDSLINE
       MED/95297772
 AB    Varicella-zoster virus (VZV) encephalitis has become more prevalent in
       the era of acquired immunodeficiency syndrome and other
       immunosuppressive diseases and poses diagnostic and therapeutic
       challenges for clinicians, radiologists, and pathologists. Six cases
       studied at our institutions shed light on the patterns and pathogenesis
       of the disease. VZV encephalitis is predominantly a vasculopathy,
       involving small and large vessels, that generates seizures, mental
       changes, and focal deficits. Brain imaging reveals large and small
       ischemic or hemorrhagic infarcts, often both, of cortex and subcortical
       gray and white matter. Deep-seated white matter lesions often
       predominate and are ischemic and/or demyelinative, depending on the size
       of blood vessels involved and the amount of additional demyelination
       caused by infection of oligodendrocytes. The demyelinative lesions are
       smaller and less coalescent than those seen in progressive multifocal
       leukoencephalopathy.
 DE    Adult  Aged  Base Sequence  Case Report  Cerebrovascular
       Disorders/*PATHOLOGY/*VIROLOGY  Demyelinating
       Diseases/PATHOLOGY/VIROLOGY  Encephalitis/*PATHOLOGY/*VIROLOGY  Female
       Herpes Zoster/PATHOLOGY  *Herpesvirus 3, Human/GENETICS  Human  Male
       Middle Age  Molecular Sequence Data  Support, U.S. Gov't, Non-P.H.S.
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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