Document 0405
 DOCN  M9590405
 TI    Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and
       activated macrophages in lymph nodes of HIV-1+ patients.
 DT    9509
 AU    Bofill M; Gombert W; Borthwick NJ; Akbar AN; McLaughlin JE; Lee CA;
       Johnson MA; Pinching AJ; Janossy G; Department of Clinical Immunology,
       Royal Free Hospital and School; of Medicine, London, United Kingdom.
 SO    Am J Pathol. 1995 Jun;146(6):1542-55. Unique Identifier : AIDSLINE
       MED/95297603
 AB    Infection with human immunodeficiency virus 1 causes profound changes in
       the lymph nodes of infected patients. In particular, large numbers of
       CD8+CD45RO+ T cells infiltrate both the paracortex and the germinal
       centers. These cells contained the cytotoxic granule-associated protein
       TIA-1 but showed no detectable levels of perforin and shared the same
       characteristics of the expanded, activated, short-lived CD8+ population
       found during acute viral infections. These cells expressed low levels of
       Bcl-2 and are likely to be short-lived in vivo as evidenced by the
       direct observation of CD8+ apoptotic cells in the paracortical areas of
       the infected nodes. Changes in the paracortical nonlymphoid populations
       were also seen. There were reactive changes in the blood vessels, and
       the macrophage population was expanded and activated. Furthermore,
       apoptotic bodies were seen in the cytoplasm of the activated
       CD68+RFD-7+RFD-1+ macrophages pointing to the phagocytic capacity of
       these cells and their role in the clearance of the apoptotic cells from
       the tissues. These observations suggest that the persistance of CD8+
       population in human immunodeficiency virus 1 infection is not a result
       of the presence of an abnormal CD8+ population but rather a result of an
       inappropriate over-stimulation of the CD8+ cells.
 DE    Adult  Antigens, CD3/*ANALYSIS  Apoptosis/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY
       HIV-1/IMMUNOLOGY  Lymph Nodes/*CYTOLOGY/IMMUNOLOGY/*VIROLOGY  Macrophage
       Activation/*IMMUNOLOGY  Male  Proto-Oncogene Proteins/ANALYSIS  Support,
       Non-U.S. Gov't  T-Lymphocyte Subsets/CHEMISTRY/*IMMUNOLOGY  JOURNAL
       ARTICLE

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