Document 0411
 DOCN  M9590411
 TI    Severe co-trimoxazole reaction in a man with AIDS.
 DT    9509
 AU    Shepherd J; Shepherd C; Tonozzi C; Boysen E; Department of Family
       Medicine, University of Colorado, Denver; 80202, USA.
 SO    J Am Board Fam Pract. 1995 Mar-Apr;8(2):130-3. Unique Identifier :
       AIDSLINE MED/95297383
 AB    Although other drugs can be used in the prophylaxis and treatment of
       HIV-infected persons, family physicians will prescribe co-trimoxazole
       frequently. These providers need to recognize the overall increased
       frequency of adverse reactions to this drug in this population and the
       potential for severe hypersensitivity effects requiring intensive
       hospital care. While the exact importance re-exposure has in causing
       this reaction remains unclear, certainly providers must pay particular
       attention to patients who have had any earlier sensitivity to the drug
       before treatment is resumed. Desensitization therapy has been used
       successfully in some HIV-positive individuals, even after severe
       reactions; however, this case again teaches the need for prudence in the
       use of all pharmacological agents.
 DE    Adult  Amitriptyline/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS
       Anaphylaxis/*CHEMICALLY INDUCED  AIDS-Related Opportunistic
       Infections/*PREVENTION & CONTROL  Case Report  Dose-Response
       Relationship, Drug  Drug Eruptions/ETIOLOGY  Drug
       Hypersensitivity/*ETIOLOGY  Drug Therapy, Combination  Fatal Outcome
       Human  Male  Pneumonia, Pneumocystis carinii/*PREVENTION & CONTROL
       Trimethoprim-Sulfamethoxazole Combination/ADMINISTRATION & DOSAGE/
       *ADVERSE EFFECTS  JOURNAL ARTICLE

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