Document 0426
 DOCN  M9590426
 TI    Erratic G-->A hypermutation within a complete caprine
       arthritis-encephalitis virus (CAEV) provirus.
 DT    9509
 AU    Wain-Hobson S; Sonigo P; Guyader M; Gazit A; Henry M; Unite de
       Retrovirologie Moleculaire, Institut Pasteur, Paris,; France.
 SO    Virology. 1995 Jun 1;209(2):297-303. Unique Identifier : AIDSLINE
       MED/95297130
 AB    The complete nucleotide sequence of an integrated provirus of caprine
       arthritis-encephalitis virus (CAEV) has been determined. The provirus
       was defective due to extensive G-->A hypermutation. Rather than being a
       smooth phenomenon distributed throughout the genome it was highly
       erratic with hypermutated and normal regions being juxtaposed, probably
       reflecting local fluctuations in the intracellular dCTP pool during
       reverse transcription of the CAEV genome. The pattern of sequence
       variation within the surface glycoproteins differs subtly from that of
       the primate lentiviruses.
 DE    Adenine  Amino Acid Sequence  Animal  Arthritis-Encephalitis Virus,
       Caprine/*GENETICS  Base Sequence  Cloning, Molecular  Comparative Study
       DNA Primers  Gene Products, env/BIOSYNTHESIS/GENETICS  Gene Products,
       rev/BIOSYNTHESIS/GENETICS  Genes, pol  *Genome, Viral  Goats/VIROLOGY
       Guanine  Molecular Sequence Data  *Mutation  Polymerase Chain Reaction
       Proviruses/*GENETICS  Signal Peptides/GENETICS  Support, Non-U.S. Gov't
       Variation (Genetics)  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).