Document 0429
 DOCN  M9590429
 TI    Serological responses to brucellosis in HIV-seropositive patients.
 DT    9509
 AU    Paul J; Gilks C; Batchelor B; Ojoo J; Amir M; Selkon JB; Public Health
       Laboratory, John Radcliffe Hospital, Oxford, UK.
 SO    Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):228-30. Unique Identifier :
       AIDSLINE MED/95297011
 AB    Serial sera from 2 patients infected with the human immunodeficiency
       virus (HIV) type 1 attending a clinic in Nairobi, Kenya, and with blood
       cultures yielding Brucella melitensis, were tested by enzyme-linked
       immunosorbent assay for their serological response (Brucella-specific
       immunoglobulin (Ig) M and IgG) to Brucella infection. Antibody responses
       were comparable to those of immunocompetent individuals, one patient
       showing serology typical of acute brucellosis, the other of chronic
       brucellosis. Sera from 100 other patients, 65 of whom were HIV-positive,
       attending the same clinic but whose routine microbiological cultures
       were negative for Brucella, were tested retrospectively for
       Brucella-specific antibody. Eight had Brucella-specific IgM and IgG, 6
       had IgM only and 21 had IgG only, suggesting relatively high levels of
       exposure to Brucella in the study cohort. There was no association
       between Brucella antibody status and HIV status. Brucellosis is probably
       underdiagnosed in Kenya. Brucella serology may be helpful in the
       diagnosis of patients with non-specific symptoms in East Africa,
       regardless of HIV status.
 DE    Antibodies, Bacterial/*ANALYSIS  Antibody Specificity
       Brucellosis/COMPLICATIONS/*IMMUNOLOGY  Female  Human  HIV
       Seropositivity/COMPLICATIONS/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       IgG/*ANALYSIS  IgM/*ANALYSIS  Retrospective Studies  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

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