Document 0438
 DOCN  M9590438
 TI    Significance of solitary and multiple esophageal ulcers in patients with
       AIDS.
 DT    9509
 AU    Martinez EJ; Nord HJ; Cooper BG; Department of Internal Medicine,
       University of South Florida; College of Medicine, Tampa, USA.
 SO    South Med J. 1995 Jun;88(6):626-9. Unique Identifier : AIDSLINE
       MED/95296713
 AB    We endoscopically evaluated odynophagia and/or dysphagia in 23 patients
       with acquired immunodeficiency syndrome (AIDS). Eleven patients (48%)
       were found to have esophageal ulcers. Seven of them had deep, sharply
       demarcated, well-circumscribed ulcer craters with raised edges; in two
       the ulcer extended to the muscularis propria. Ulcers were single in four
       patients, multiple in six, and unspecified in one. Biopsies were
       nondiagnostic. In eight patients, mycobacterial, viral, and fungal
       cultures were negative. Specific infections diagnosed in three patients
       were treated with appropriate agents. Ulcers were treated
       symptomatically, and seven patients received therapy for suspected viral
       etiology. Symptoms remained unchanged in five patients, improved in
       three, and resolved in two. Fifty-five percent of patients died within
       3.6 months (mean) of diagnosis. Large solitary and multiple esophageal
       ulcers are common in AIDS patients with odynophagia and dysphagia.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult
       Bacillus/ISOLATION & PURIF  Candida albicans/ISOLATION & PURIF
       Candidiasis/DIAGNOSIS  Cytomegalovirus/ISOLATION & PURIF
       Cytomegalovirus Infections/DIAGNOSIS  Deglutition Disorders/DIAGNOSIS
       Endoscopy, Digestive System  Esophageal
       Diseases/*COMPLICATIONS/MICROBIOLOGY/PATHOLOGY/  VIROLOGY  Female
       Follow-Up Studies  Human  Male  Middle Age  Simplexvirus/ISOLATION &
       PURIF  Survival Rate
       Ulcer/COMPLICATIONS/MICROBIOLOGY/PATHOLOGY/VIROLOGY  JOURNAL ARTICLE

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