Document 0439
 DOCN  M9590439
 TI    Natural protection against HIV-1 infection provided by HIV-2 [see
       comments]
 DT    9509
 AU    Travers K; Mboup S; Marlink R; Gueye-Nidaye A; Siby T; Thior I; Traore
       I; Dieng-Sarr A; Sankale JL; Mullins C; et al; Department of Cancer
       Biology, Harvard School of Public Health,; Boston, MA 02115, USA.
 SO    Science. 1995 Jun 16;268(5217):1612-5. Unique Identifier : AIDSLINE
       MED/95296692
 CM    Comment in: Science 1995 Jun 16;268(5217):1566
 AB    Significant differences have been observed in the rates of transmission
       and disease development in human immunodeficiency virus (HIV) types 1
       and 2. Because many HIV-2-infected people remain asymptomatic for
       prolonged periods, the hypothesis that HIV-2 might protect against
       subsequent infection by HIV-1 was considered. During a 9-year period in
       Dakar, Senegal, the seroincidence of both HIV types was measured in a
       cohort of commercial sex workers. Despite a higher incidence of other
       sexually transmitted diseases (STDs), HIV-2-infected women had a lower
       incidence of HIV-1 than did HIV-seronegative women, with a relative risk
       of 0.32 (P = 0.008). An understanding of the cross-protective mechanisms
       involved may be directly relevant to HIV-1 vaccine development.
 DE    Antigenic Determinants/IMMUNOLOGY  AIDS Vaccines  Cohort Studies
       Confounding Factors (Epidemiology)  Cross Reactions  CD4 Lymphocyte
       Count  Female  Human  HIV Antigens/IMMUNOLOGY  HIV
       Infections/EPIDEMIOLOGY/*IMMUNOLOGY/PREVENTION & CONTROL/  VIROLOGY  HIV
       Seropositivity  HIV-1/*IMMUNOLOGY/PATHOGENICITY
       HIV-2/*IMMUNOLOGY/PATHOGENICITY  Immunity, Natural  Multivariate
       Analysis  Prospective Studies  Prostitution  Regression Analysis
       Senegal  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.
       Virulence  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).