Document 0459
 DOCN  M9590459
 TI    Effect of amphotericin B on the lipids of five different strains of
       Cryptococcus neoformans.
 DT    9509
 AU    Franzot SP; Hamdan JS; Department of Microbiology, Institute of
       Biological Sciences,; Federal University of Minas Gerais, Belo
       Horizonte, Brazil.
 SO    Mycopathologia. 1994 Nov;128(2):85-9. Unique Identifier : AIDSLINE
       MED/95295811
 AB    Cells of five strains of Cryptococcus neoformans were obtained for
       partial analysis of lipid composition. Quantitative analysis of lipids
       and sterols were completed, as well as qualitative analysis of sterols
       by thin-layer chromatography and by the ultraviolet spectra. Such
       determinations were made on cells cultured in the absence and presence
       of amphotericin B at sub-MIC (minimal inhibitory concentration) levels.
       Marked alterations of the lipid and sterol contents were observed in the
       amphotericin B-treated cells. Moreover, ergosterol disappeared in these
       antibiotic-exposed cells. It is concluded that amphotericin B altered
       the lipid profiles, especially sterols of C. neoformans.
 DE    Amphotericin B/*PHARMACOLOGY  AIDS-Related Opportunistic
       Infections/MICROBIOLOGY  Cerebrospinal Fluid/MICROBIOLOGY  Comparative
       Study  Cryptococcosis/MICROBIOLOGY  Cryptococcus
       neoformans/CHEMISTRY/*DRUG EFFECTS/ISOLATION & PURIF
       Ergosterol/ANALYSIS  Human  Kidney Transplantation  Membrane
       Lipids/*ANALYSIS  Microbial Sensitivity Tests  Postoperative
       Complications/MICROBIOLOGY  Sterols/ANALYSIS  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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