Document 0469
 DOCN  M9590469
 TI    Preliminary evidence for idiotype-antiidiotype immune complexes
       cross-reactive with lymphocyte antigens in AIDS and lupus.
 DT    9509
 AU    Root-Bernstein RS; Department of Physiology, Michigan State University,
       East Lansing; 48824, USA.
 SO    Med Hypotheses. 1995 Jan;44(1):20-7. Unique Identifier : AIDSLINE
       MED/95295582
 AB    Several investigators have proposed that autoimmunity may be induced by
       idiotype-antiidiotype antibody networks. It is generally assumed that
       the antiidiotype is produced in response to the idiotype, and therefore
       that autoimmune diseases have single antigenic initiators. The theory of
       multiple-antigen-mediated autoimmunity (MAMA) proposes, on the other
       hand, that idiotype and antiidiotype result from two primary immune
       responses to two chemically complementary antigens. Because of the
       complementarity of the antigens, and the complementarity of the
       antibodies for the antigens, the antibodies will themselves be
       complementary. They will thus form circulating immune complexes, the
       self-nonself distinction diffusion (DAD) experiments (a modification of
       Ouchterlony immunodiffusion), in which 1800 pairs of antibodies were
       screened for their ability to form precipitating complexes. Four sets of
       antibodies associated with AIDS (HIV + Staphylococcus; HIV + Mycoplasma;
       CMV + Mycoplasma; and HBV + Mycoplasma) specifically precipitated each
       other, and one of the antibodies in each set also precipitated
       monoclonal antibodies against one or more lymphocyte protein markers.
       These results therefore demonstrate that idiotype-antiidiotype
       antibodies can be elicited by independent antigens and may induce
       AIDS-related forms of autoimmunity directed at lymphocytes.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Antibodies,
       Anti-Idiotypic/*IMMUNOLOGY  Antibodies, Bacterial/IMMUNOLOGY
       Antibodies, Fungal/IMMUNOLOGY  Antibodies, Monoclonal  Antibodies,
       Viral/IMMUNOLOGY  Antigen-Antibody Complex/*IMMUNOLOGY
       Antigens/IMMUNOLOGY  Autoantibodies/IMMUNOLOGY  Autoimmunity  Cross
       Reactions  Human  Immunodiffusion  Immunoglobulin Idiotypes/*IMMUNOLOGY
       Lupus Erythematosus, Systemic/*IMMUNOLOGY  Lymphocytes/*IMMUNOLOGY
       JOURNAL ARTICLE

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