Document 0471
 DOCN  M9590471
 TI    Association of primary sclerosing cholangitis, thymoma and
       hypogammaglobulinemia.
 DT    9509
 AU    Yoshioka R; Sato Y; Kogure A; Ohira H; Takagi T; Kuroda M; Miyata M;
       Obara K; Nishimaki T; Kasukawa R; Department of Internal Medicine II,
       Fukushima Medical College,; Japan.
 SO    Liver. 1995 Feb;15(1):53-5. Unique Identifier : AIDSLINE MED/95295522
 AB    A 64-year-old Japanese woman with thymoma has been suffering from
       diarrhea and increased alkaline phosphatase levels without jaundice. Her
       serum immunoglobulin levels of IgM and IgG were less than half of the
       normal levels, with an increase in CD8 (suppressor/cytotoxic) T cell
       percentage and a decrease in CD4 (helper) T cell percentage, resulting
       in a lower CD4/CD8 ratio of 0.31. These immunological features are in
       accordance with those of hypogammaglobulinemia complicating thymoma.
       Cholangiography and a liver biopsy specimen disclosed the presence of
       primary sclerosing cholangitis (PSC). PSC has been recognized in various
       immunodeficiency syndromes and this case shows that thymoma complicated
       by hypogammaglobulinemia is associated with PSC.
 DE    Agammaglobulinemia/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY  Bile Ducts,
       Intrahepatic/PATHOLOGY  Case Report  Cholangitis,
       Sclerosing/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY  CD4 Lymphocyte Count
       CD4-CD8 Ratio  Female  Human  IgG/BLOOD  IgM/BLOOD  Liver Function Tests
       Middle Age  Thymoma/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY  Thymus
       Gland/PATHOLOGY  Thymus Neoplasms/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY
       JOURNAL ARTICLE

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