Document 0493
 DOCN  M9590493
 TI    Vertical transmission of human immunodeficiency virus type 1: autologous
       neutralizing antibody, virus load, and virus phenotype.
 DT    9509
 AU    Husson RN; Lan Y; Kojima E; Venzon D; Mitsuya H; McIntosh K; Children's
       Hospital, Department of Pediatrics, Harvard Medical; School, Boston,
       Massachusetts 02115, USA.
 SO    J Pediatr. 1995 Jun;126(6):865-71. Unique Identifier : AIDSLINE
       MED/95294692
 AB    OBJECTIVE: To evaluate immunologic and virologic correlates of vertical
       transmission of human immunodeficiency virus type 1 (HIV-1). DESIGN:
       Case-control study. PATIENTS: Women who were prospectively enrolled in a
       natural history study of HIV-1 infection in women and infants. Sixteen
       HIV-1-infected women whose infants became infected were matched by CD4+
       cell percentage and use of zidovudine during pregnancy with women whose
       infants did not become infected. MEASUREMENTS: Maternal autologous
       neutralizing antibody, virus load determined by RNA-polymerase chain
       reaction (RNA-PCR), and virus phenotype. RESULTS: Most women in both
       groups had low titers of autologous neutralizing antibody, and no
       difference in neutralizing titers was observed (range, < 4 to 181 in
       both groups). The HIV-1 copy number in maternal plasma was not
       significantly different in the two groups but was inversely correlated
       with maternal CD4+ cell percentage (p < 0.005). Five women in the
       transmitting group and four in the non-transmitting group had
       syncytium-inducing (SI) phenotype virus. Two infected infants had SI
       phenotype virus. The SI phenotype virus was associated with a greater
       HIV-1 copy number in maternal plasma (p < 0.05) and an increase in the
       mortality rate for the infants (p < 0.01). CONCLUSIONS: In women matched
       for CD4+ cell percentage, low titers of autologous neutralizing
       antibody, high virus load, and SI phenotype virus were not associated
       with an increased risk of transmission of HIV-1 to their infants.
 DE    Acquired Immunodeficiency Syndrome/MORTALITY/*TRANSMISSION  CD4
       Lymphocyte Count  *Disease Transmission, Vertical  Female  Human  HIV
       Antibodies/*ANALYSIS  HIV Core Protein p24/ANALYSIS
       *HIV-1/GENETICS/IMMUNOLOGY/ISOLATION & PURIF  Infant  Phenotype
       Polymerase Chain Reaction  RNA, Viral/ANALYSIS  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).