Document 0494
 DOCN  M9590494
 TI    Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid
       tetramers from Arnebia euchroma as anti-HIV agents.
 DT    9509
 AU    Kashiwada Y; Nishizawa M; Yamagishi T; Tanaka T; Nonaka G; Cosentino LM;
       Snider JV; Lee K; Natural Products Laboratory, School of Pharmacy,
       University of; North Carolina, Chapel Hill 27599, USA.
 SO    J Nat Prod. 1995 Mar;58(3):392-400. Unique Identifier : AIDSLINE
       MED/95294590
 AB    Monosodium and monopotassium salts [2-4] of isomeric caffeic acid
       tetramers were isolated from Arnebia euchroma as anti-HIV agents.
       Mixtures of dipotassium and disodium salts [1] of a caffeic acid
       tetramer and dipotassium and potassium-sodium salts [5] of a caffeic
       acid tetramer glucoside were also isolated from the active fraction. The
       structures of 1-5 were characterized by chemical and spectral evidence.
       Compounds 2-4 demonstrated potent anti-HIV activity with EC50 values of
       2.8, 4.0, and 1.5 micrograms/ml, respectively. Treatment of 1-4 with
       dilute HCl yielded known caffeic acid tetramers [8 and 9], which were
       found to be less active, indicating the importance of the sodium and
       potassium salts to the enhanced anti-HIV activity.
 DE    Antiviral Agents/*CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY  Caffeic
       Acids/*CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY  Cell Line  Drugs,
       Chinese Herbal/CHEMISTRY/*PHARMACOLOGY  Human  HIV/*DRUG EFFECTS
       Nuclear Magnetic Resonance  Spectrometry, Mass, Fast Atom Bombardment
       Support, U.S. Gov't, P.H.S.  Virus Replication/DRUG EFFECTS  JOURNAL
       ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).