Document 0496
 DOCN  M9590496
 TI    Fulminant human herpesvirus six encephalitis in a human immunodeficiency
       virus-infected infant.
 DT    9509
 AU    Knox KK; Harrington DP; Carrigan DR; Department of Pathology, Medical
       College of Wisconsin, Milwaukee; 53226, USA.
 SO    J Med Virol. 1995 Mar;45(3):288-92. Unique Identifier : AIDSLINE
       MED/95294555
 AB    Self-limited involvement of the central nervous system (CNS) is a
       relatively common complication of primary infection with human
       herpesvirus six (HHV-6) in normal children. We describe an HIV-infected
       infant who developed fulminant encephalitis as a complication of HHV-6
       infection. Immunohistochemical staining of CNS tissue demonstrated
       productive infection of all CNS cell-types. Analysis of the infected
       brain tissue by the polymerase chain reaction (PCR) confirmed the
       presence of a dense HHV-6 infection in the tissue, and demonstrated that
       the virus present in the CNS tissue was predominantly the A variant of
       HHV-6. This is the first demonstration of invasive tissue disease caused
       by HHV-6 in an HIV-infected infant.
 DE    AIDS-Related Opportunistic Infections/*COMPLICATIONS/PATHOLOGY/
       VIROLOGY  Base Sequence  Brain/PATHOLOGY/VIROLOGY  Case Report  DNA
       Primers/GENETICS  DNA, Viral/GENETICS  Encephalitis,
       Viral/*COMPLICATIONS/PATHOLOGY/VIROLOGY  Female  Herpesviridae
       Infections/*COMPLICATIONS/PATHOLOGY/VIROLOGY  *Herpesvirus 6,
       Human/GENETICS/IMMUNOLOGY/PATHOGENICITY  Human  *HIV-1
       Immunohistochemistry  Infant  Molecular Sequence Data  Polymerase Chain
       Reaction  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).