Document 0498
 DOCN  M9590498
 TI    Prognostic value of adenosine deaminase compared to other markers for
       progression to acquired immunodeficiency syndrome among intravenous drug
       users.
 DT    9509
 AU    Casoli C; Lisa A; Magnani G; Starcich R; Fiaccadori F; Bertazzoni U; Zei
       G; Istituto di Patologia Medica, Universita di Parma, Italy.
 SO    J Med Virol. 1995 Feb;45(2):203-10. Unique Identifier : AIDSLINE
       MED/95294541
 AB    This study was designed to determine the prognostic value of erythrocyte
       adenosine deaminase (ADA) as a possible indicator of progression to
       AIDS, and compare this with other known cellular and serological
       markers. At the end of a 3-year study, a cohort of 114 human
       immunodeficiency virus-1 (HIV-1) seropositive intravenous drug users
       (IVDUs) from the five different Center for Disease Control (CDC) groups
       was examined in order to estimate the prognostic relevance with respect
       to the progression to acquired immunodeficiency syndrome (AIDS) of each
       of the following markers at baseline value: number and percentage of
       CD4+ T cells, number of CD8+ T cells, CD4+/CD8+ ratio, IgA and beta 2
       microglobulin and ADA levels, and the presence of HIV antigens.
       Moreover, 57 IVDUs belonging to II and III CDC groups were analyzed in a
       follow-up study at 6-month intervals, in order to evaluate and compare
       the behavior of each marker over time. The prognostic significance of
       each marker was assessed by computing the survival distribution and the
       Cox analysis in a multivariate model providing the set of markers with
       greatest predictive value. The levels of ADA and the CD4+/CD8+ ratio
       showed a linear association with disease staging, whereas beta 2
       microglobulin and CD4+/CD8+ ratio were the best predictors for AIDS
       progression. A highly significant increase in ADA and beta 2
       microglobulin was observed during follow-up. The results obtained among
       HIV-positive IVDUs clearly indicate that the erythrocyte ADA may be
       considered a reliable marker of the development of HIV infection from
       the intermediate stages of the disease onwards.(ABSTRACT TRUNCATED AT
       250 WORDS)
 DE    beta 2-Microglobulin/METABOLISM  Acquired Immunodeficiency
       Syndrome/BLOOD/*COMPLICATIONS/  *ENZYMOLOGY  Adenosine Deaminase/*BLOOD
       Adolescence  Adult  Biological Markers  Cohort Studies  Comparative
       Study  Erythrocytes/ENZYMOLOGY  Female  Follow-Up Studies  Human  HIV
       Seropositivity/COMPLICATIONS  *HIV-1  Lymphocyte Count  Male
       Multivariate Analysis  Prognosis  Substance Abuse,
       Intravenous/*COMPLICATIONS  Support, Non-U.S. Gov't  CLINICAL TRIAL
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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