Document 0501
 DOCN  M9590501
 TI    DNA inoculation as a novel vaccination method against human retroviruses
       with rheumatic disease associations.
 DT    9509
 AU    Ugen KE; Wang B; Ayyavoo V; Agadjanyan M; Boyer J; Li F; Kudchodkar S;
       Lin J; Merva M; Fernandes L; et al; Department of Pathology and
       Laboratory Medicine, University of; Pennsylvania School of Medicine,
       Philadelphia 19104, USA.
 SO    Immunol Res. 1994;13(2-3):154-62. Unique Identifier : AIDSLINE
       MED/95294402
 AB    There are a number of rheumatologic manifestations of human retroviral
       infections associated with human immunodeficiency virus type I (HIV-I)
       and the human T-cell leukemia virus type I (HTLV-I) including arthritis,
       Sjogren's syndrome-like symptoms as well as other varied autoimmune
       phenomena. Infection with HTLV-1 may be directly involved in the
       etiology and/or pathogenesis of an arthritic condition similar to
       rheumatoid arthritis. We have been characterizing a new vaccination
       strategy against human retroviral infections, designated DNA
       inoculation. This procedure involves the intramuscular injection of DNA
       plasmids which express specific human retroviral antigens. This
       technique results in the development of humoral and cellular immune
       responses against these proteins. Specifically, this method has been
       successfully used to develop immune responses against HIV-I and HTLV-I.
       The availability of rat and rabbit infection models for HTLV-I, coupled
       with the successful development of immune responses in these animals
       after DNA inoculation with an HTLV-I envelope expressing plasmid, will
       allow the efficacy of this vaccination technique to be evaluated with
       protection against in vivo viral challenge as an endpoint.
 DE    Animal  DNA, Viral/*THERAPEUTIC USE  Human  HIV
       Infections/COMPLICATIONS/*PREVENTION & CONTROL  HTLV-I
       Infections/COMPLICATIONS/*PREVENTION & CONTROL  Rheumatic
       Diseases/VIROLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Viral Vaccines/*GENETICS  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).