Document 0502
 DOCN  M9590502
 TI    Human T-lymphotropic virus type I-associated uveitis in patients with
       Graves' disease treated with methylmercaptoimidazole.
 DT    9509
 AU    Mizokami T; Okamura K; Kohno T; Sato K; Ikenoue H; Kuroda T; Inokuchi K;
       Fujishima M; Second Department of Internal Medicine, Faculty of
       Medicine,; Kyushu University, Fukuoka, Japan.
 SO    J Clin Endocrinol Metab. 1995 Jun;80(6):1904-7. Unique Identifier :
       AIDSLINE MED/95294222
 AB    Human T-lymphotropic virus type I (HTLV-I) is responsible for a certain
       form of uveitis [HTLV-I-associated uveitis (HAU)]. A previous history of
       Graves' disease has been reported in 9-17% of the patients with HAU. In
       this study, the prevalence of patients with either HTLV-I antibody or
       uveitis was evaluated in 819 consecutive patients with thyroid disorders
       between 1991 and 1992. Serum HTLV-I antibody was found in 25 of 392
       patients with Graves' disease, 19 of 257 with chronic thyroiditis, and 3
       of 170 with nodular goiter. Five of 25 HTLV-I-positive patients with
       Graves' disease developed HAU. All of these 5 patients had been treated
       with methylmercaptoimidazole (MMI). Within a few months before the onset
       of uveitis, 3 patients were hyperthyroid, and 2 were hypothyroid. In 2
       of 5 patients, an exacerbation of uveitis occurred soon after the
       readministration of MMI for the relapse of hyperthyroidism. None of the
       367 HTLV-I negative patients with Graves' disease nor 22 HTLV-I-positive
       patients with chronic thyroiditis or nodular goiter developed uveitis.
       It was therefore suggested that Graves' disease, thyroid dysfunction
       and/or MMI administration might be related to the development of HAU.
 DE    Adult  Aged  DNA, Viral/ANALYSIS  Female  Graves' Disease/DRUG
       THERAPY/*VIROLOGY  Human  HTLV-I/GENETICS  HTLV-I Antibodies/BLOOD
       *HTLV-I Infections  Methimazole/*THERAPEUTIC USE  Middle Age  Polymerase
       Chain Reaction  Uveitis/*VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).