Document 0517
 DOCN  M9590517
 TI    Evaluation of anti-HTLV-1 antibody in primary glomerulonephritis.
 DT    9509
 AU    Namie S; Shimamine R; Ichinose H; Nishikawa Y; Ideguchi M; Ozono Y;
       Harada T; Hara K; Second Department of Internal Medicine, Nagasaki
       University; School of Medicine, Japan.
 SO    J Int Med Res. 1995 Jan-Feb;23(1):56-60. Unique Identifier : AIDSLINE
       MED/95293174
 AB    Human T-cell leukaemia virus type-1 (HTLV-1) is known to cause adult
       T-cell leukaemia. The prevalence of anti-HTLV-1 antibody in
       haemodialysis patients has been reported to be higher than that in the
       general population. The anti-HTLV-1 antibody-positive rate in patients
       with primary glomerulonephritis in the Nagasaki district, an endemic
       area of HTLV-1, was evaluated. The antibody-positive rates in patients
       with primary glomerulonephritis (9.9%) and in haemodialysis patients
       (18.4%) were significantly higher than the rate in general blood donors
       (6.6%). Of 142 patients with primary glomerulonephritis, 14 (9.9%) were
       positive for the antibody; histological evaluation of these patients
       showed minor glomerular abnormality in one, mesangial proliferative
       glomerulonephritis in eight (IgA nephropathy in six and non-IgA
       nephropathy in two), membranous nephropathy in three, and crescentic
       glomerulonephritis in two. Evaluation of 10 antibody-positive patients
       by immunofluorescent microscopy showed immunocomplex-type nephritis in
       nine, suggesting the involvement of HTLV-1-associated antigen in the
       development and progression of glomerulonephritis.
 DE    Adolescence  Adult  Evaluation Studies  Female
       Glomerulonephritis/*EPIDEMIOLOGY/IMMUNOLOGY/*VIROLOGY  Human  HTLV-I
       Antibodies/*BLOOD  HTLV-I Infections/*EPIDEMIOLOGY/IMMUNOLOGY
       Japan/EPIDEMIOLOGY  Male  Middle Age  Prevalence  JOURNAL ARTICLE

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