Document 0518
 DOCN  M9590518
 TI    Obstetric and perinatal outcome in human immunodeficiency virus-infected
       pregnant women with and without opiate addiction.
 DT    9509
 AU    Mauri A; Piccione E; Deiana P; Volpe A; Department of Obstetrics and
       Gynecology, University of Cagliari,; Italy.
 SO    Eur J Obstet Gynecol Reprod Biol. 1995 Feb;58(2):135-40. Unique
       Identifier : AIDSLINE MED/95293153
 AB    This study was undertaken to assess the impact on gestation played by
       the simple human immunodeficiency virus (HIV)-seropositive status either
       alone or complicated by opiate abuse in the absence of other confounding
       variables. To this purpose the main obstetric complications and the
       perinatal outcome were prospectively evaluated in 38 simple HIV-infected
       women, 14 of whom were simple carriers and 24 under methadone treatment,
       and in 76 uninfected women, 16 of whom were methadone users and 60
       controls. In simple HIV-carriers maternal weight gain (P < 0.001) and
       both 1- and 5-min Apgar scores (P < 0.005) were reduced whereas the
       incidence of miscarriage was increased (P < 0.05). Worse obstetric and
       perinatal outcomes were found in HIV-seropositive drug addicts, in which
       gestational length (P < 0.001), maternal weight gain (P < 0.001) and
       Apgar scores were lower (P < 0.005 and P < 0.001, respectively) and the
       rate of preterm labour, small for gestational age newborns, vaginal and
       urinary infections as well as of unexplained fever (P < 0.05) was
       higher. Outcomes were similar in HIV-seropositive and seronegative drug
       addicts and in both groups a positive correlation (r = 0.62 P < 0.001,
       and r = 0.44, respectively) was found between the number of infectious
       episodes throughout pregnancy and the mean dose of opiate consumed
       daily. Our results suggest that HIV-seropositive condition might exert
       slight direct and indirect detrimental effects on pregnancy. Whatever
       the maternal serologic status, opiate intake not only causes a further
       worsening of gestational and perinatal outcomes, but also increases the
       susceptibility towards pathogens.
 DE    Female  Human  *HIV Seropositivity  *Narcotics  Pregnancy  *Pregnancy
       Complications, Infectious  *Pregnancy Outcome  Prospective Studies
       *Substance Abuse  JOURNAL ARTICLE

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