Document 0525
 DOCN  M9590525
 TI    Depletion of CD8+ T cells suppresses the development of experimental
       autoimmune myasthenia gravis in Lewis rats.
 DT    9509
 AU    Zhang GX; Ma CG; Xiao BG; Bakhiet M; Link H; Olsson T; Division of
       Neurology, Karolinska Institute, Huddinge, University; Hospital, Sweden.
 SO    Eur J Immunol. 1995 May;25(5):1191-8. Unique Identifier : AIDSLINE
       MED/95293010
 AB    To understand the role of CD8+ T cells in experimental autoimmune
       myasthenia gravis (EAMG), CD8+ T cells were depleted by injecting a
       monoclonal anti-rat CD8 antibody (OX8) into Lewis rats immunized with
       Torpedo acetylcholine receptor (AChR) in complete Freund's adjuvant
       (CFA). CD8-depleted EAMG rats showed strikingly less muscle weakness and
       lower anti-AChR IgG antibody levels compared to Hy2-15-injected control
       EAMG rats. Moreover, the numbers of AChR-specific IgG antibody-secreting
       cells, AChR-reactive interferon-gamma-secreting T helper type 1-like
       cells and lymphocyte proliferation to AChR were lower in the
       CD8-depleted group than in control EAMG rats. These differences were
       significant among mononuclear cells from inguinal and popliteal lymph
       nodes, mesenteric lymph nodes and spleen, but not from thymus when
       examined 3, 5 and 7 weeks post-immunization. We suggest that CD8+ T
       cells are involved in the induction and persistance of EAMG by directly
       or indirectly affecting AChR-reactive T cells and anti-AChR IgG
       antibody-secreting cells.
 DE    Animal  Antibodies, Monoclonal/PHARMACOLOGY  Autoimmune
       Diseases/IMMUNOLOGY/*PREVENTION & CONTROL  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Female  Hypersensitivity, Delayed/IMMUNOLOGY
       IgG/BIOSYNTHESIS/IMMUNOLOGY  *Immune Tolerance  Immunization  Interferon
       Type II/SECRETION  Lymphocyte Count  Lymphocyte Transformation  Lymphoid
       Tissue/IMMUNOLOGY/PATHOLOGY  Muscles/PHYSIOPATHOLOGY  Myasthenia
       Gravis/IMMUNOLOGY/*PREVENTION & CONTROL  Rats  Rats, Inbred Lew
       Receptors, Cholinergic/IMMUNOLOGY  Support, Non-U.S. Gov't  Th1
       Cells/IMMUNOLOGY  Torpedo  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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